Environmental or self-antigens and homotypic interactions trigger BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other signals in the microenvironment and growing the activation of anti-apoptotic and proliferation pathways. Richter transformation remains an ominous function for people with CLL, specifically when it can be clonally https://omarj308els5.nytechwiki.com/user