The acknowledged affect of those PTMs on ATXN2’s operate and SCA2 pathogenesis stays constrained. In other polyQ disorders, various research proposed that proteolytic cleavage of polyQ proteins could Engage in a vital position in pathogenesis [36, 45]. Aligned with this particular strategy, the existence of the enriched forty two kDa fragment https://federicoh444sdp7.blgwiki.com/user